RNF103-CHMP3

Across TCGA pan-cancer cohorts, RNF103-CHMP3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RNF103-CHMP3 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RNF103-CHMP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF103-CHMP3 expression acts as an unfavorable survival marker, although some lineages such as LGG and THYM show a favorable association.

KIRP, LIHC, and LUAD are the cancer types where RNF103-CHMP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.579	0.840	<.001	105	view →
LIHC	OS	Tertile	All	0.368	0.607	<.001	64	view →
LUAD	DFS	Quartile	All	0.710	0.850	<.001	47	view →
COAD	DFS	Median	All	0.693	0.866	<.001	36	view →
LGG	DFS	Tertile	All	0.789	0.624	<.001	28	view →
THYM	OS	Median	II,III,IV	0.942	0.528	.003	20	view →
UCEC	DFS	Median	All	0.796	0.876	.005	18	view →
BLCA	OS	Quartile	All	0.640	0.357	.005	16	view →
PAAD	DFS	Quartile	All	0.224	0.508	.014	13	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	12	view →
ESCA	DFS	Quartile	II,III,IV	0.231	0.478	.027	12	view →
HNSC	OS	Median	IV	0.478	0.334	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RNF103-CHMP3–KIRP (OS)

Open the KIRP breakdown →