RNF103-CHMP3

Across TCGA pan-cancer cohorts, RNF103-CHMP3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RNF103-CHMP3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RNF103-CHMP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF103-CHMP3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LUAD, LUSC, and BLCA are the cancer types where RNF103-CHMP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF103-CHMP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.317	<.001	8	view →
LUSC	Male	II,III,IV	+0.250	<.001	5	view →
BLCA	All	All	+0.205	.013	5	view →
LIHC	All	All	+0.178	<.001	4	view →
COAD	Male	All	+0.176	.006	4	view →
KIRP	All	III,IV	+0.463	.012	3	view →
KICH	Female	All	−0.101	.007	3	view →
CHOL	All	All	+0.098	<.001	2	view →
ESCA	Female	All	+0.526	.008	1	view →
THCA	Female	All	−0.039	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RNF103-CHMP3–LUAD

Open the LUAD breakdown →