RNF10

Across TCGA pan-cancer cohorts, RNF10 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated RNF10 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RNF10 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, BRCA, and KICH are the cancer types where RNF10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	III,IV	0.010	0.754	<.001	24	view →
BRCA	OS	Median	III,IV	0.198	0.833	<.001	16	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCEC	DFS	Median	All	0.969	0.615	.006	12	view →
HNSC	DFS	Median	II,III,IV	0.170	0.662	.016	9	view →
PCPG	DFS	Median	All	0.094	0.768	.008	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
COAD	DFS	Median	All	0.160	0.693	.034	3	view →
SKCM	DFS	Median	III,IV	0.088	0.597	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

RNF10–LUSC (DFS)

Open the LUSC breakdown →