RNF10

Across TCGA pan-cancer cohorts, RNF10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RNF10 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RNF10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RNF10 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where RNF10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.791	.011	10	view →
LSCC	DFS	Median	All	0.907	0.464	.009	9	view →
PDAC	DFS	Quartile	II,III,IV	0.756	0.522	.031	3	view →
UCEC	DFS	Quartile	All	0.597	0.885	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RNF10–CCRCC (OS)

Open the CCRCC breakdown →