RNF10

Across TCGA pan-cancer cohorts, RNF10 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNF10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNF10 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RNF10 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LSCC are the cancer types where RNF10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.505	.002	8	view →
COAD	All	III,IV	−0.517	.003	4	view →
LSCC	Male	All	+0.306	<.001	4	view →
PDAC	Male	All	−0.515	.025	2	view →
CCRCC	Female	All	+0.562	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RNF10–HNSC

Open the HNSC breakdown →