RNASEK-C17orf49

Across TCGA patient cohorts, RNASEK-C17orf49 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,024 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible RNASEK-C17orf49-associated GO terms across cancer lineages are Tail-anchored membrane protein insertion into ER membrane, Protein insertion into ER membrane by stop-transfer membrane-anchor sequence, and Mitochondrial proton-transporting ATP synthase complex assembly. Each is linked with RNASEK-C17orf49 in more than 21 cancer types. Because this analysis shows association rather than direction, both RNASEK-C17orf49-to-partner and partner-to-RNASEK-C17orf49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tail-anchored membrane protein insertion into ER membrane grouped by RNASEK-C17orf49-low versus RNASEK-C17orf49-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEK-C17orf49→partner) and Y-score (partner→RNASEK-C17orf49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Tail-anchored membrane protein insertion into ER membrane →	+0.052	+0.180	.001	<.001	2	22
READ	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.036	+0.268	<.001	<.001	3	21
DLBC	Mitochondrial proton-transporting ATP synthase complex assembly →	+0.053	+0.366	.004	.004	1	21
ACC	Lysosomal lumen acidification →	+0.052	+0.355	<.001	.001	2	17
DLBC	Proton-transporting two-sector ATPase complex assembly →	+0.058	+0.445	<.001	<.001	1	18
UCS	Protein histidyl modification to diphthamide →	+0.057	+0.391	.004	.006	1	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,024 associations by consensus.

Tail-anchored membrane protein insertion into ER membrane by RNASEK-C17orf49 expression — ESCA

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