RNASEH2B-AS1

Across TCGA pan-cancer cohorts, RNASEH2B-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RNASEH2B-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNASEH2B-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RNASEH2B-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where RNASEH2B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.691	0.497	<.001	96	view →
SKCM	OS	Tertile	IV	0.831	0.106	.002	59	view →
UVM	DFS	Quartile	II,III,IV	0.315	0.786	.001	54	view →
LGG	DFS	Tertile	All	0.665	0.820	<.001	35	view →
THYM	DFS	Tertile	II,III,IV	0.887	0.365	.002	34	view →
LAML	DFS	Tertile	All	0.482	0.255	.004	28	view →
THCA	DFS	Tertile	II,III,IV	0.793	0.962	.006	26	view →
LIHC	OS	Tertile	III,IV	0.193	0.689	<.001	24	view →
MESO	DFS	Quartile	II,III,IV	0.327	0.937	.006	21	view →
UCS	DFS	Median	IV	0.909	0.416	.008	18	view →
KIRP	DFS	Median	IV	0.039	0.471	.015	18	view →
COAD	OS	Median	IV	0.846	0.272	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RNASEH2B-AS1–HNSC (DFS)

Open the HNSC breakdown →