RNASEH2B-AS1

Across TCGA pan-cancer cohorts, RNASEH2B-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RNASEH2B-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNASEH2B-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNASEH2B-AS1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where RNASEH2B-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASEH2B-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.078	<.001	9	view →
LIHC	Female	II,III,IV	+0.083	<.001	8	view →
THCA	All	All	−0.193	<.001	7	view →
COAD	All	All	+0.123	<.001	6	view →
CHOL	All	All	+0.262	.002	4	view →
BRCA	All	II,III,IV	+0.102	.019	4	view →
STAD	All	All	+0.230	.015	2	view →
LUSC	All	III,IV	−0.125	.014	2	view →
KICH	All	All	−0.089	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RNASEH2B-AS1–HNSC

Open the HNSC breakdown →