RNASEH2A

Across TCGA pan-cancer cohorts, RNASEH2A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RNASEH2A data layer compared with 27 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher RNASEH2A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNASEH2A expression acts as an unfavorable survival marker.

PRAD, UCEC, and ACC are the cancer types where RNASEH2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.140	0.666	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RNASEH2A–PRAD (DFS)

Open the PRAD breakdown →