RNASEH1

Across TCGA pan-cancer cohorts, RNASEH1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated RNASEH1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RNASEH1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNASEH1 expression acts as an unfavorable survival marker.

LUSC and BLCA are the cancer types where RNASEH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.112	0.743	<.001	24	view →
BLCA	OS	Median	All	0.182	0.618	.008	21	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

RNASEH1–LUSC (OS)

Open the LUSC breakdown →