RNASEH1

Across TCGA pan-cancer cohorts, RNASEH1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNASEH1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNASEH1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNASEH1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where RNASEH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASEH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.892	<.001	12	view →
COAD	Female	II,III,IV	+1.085	<.001	11	view →
LUAD	Male	III,IV	+1.058	<.001	11	view →
LIHC	Male	II,III,IV	+1.197	<.001	9	view →
LUSC	Male	II,III,IV	+1.051	<.001	8	view →
BLCA	Female	All	+0.881	<.001	8	view →
STAD	Male	II,III,IV	+0.862	<.001	7	view →
THCA	Female	All	−0.442	<.001	7	view →
UCEC	All	II,III,IV	+0.979	.001	6	view →
CHOL	All	II,III,IV	+2.165	<.001	5	view →
KIRP	All	II,III,IV	+0.621	.006	5	view →
KICH	All	All	−0.633	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNASEH1–HNSC

Open the HNSC breakdown →