RNASEH1

Across TCGA patient cohorts, RNASEH1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,900 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RNASEH1-associated proteins across cancer lineages are SNRNP200, MSH2, and PPM1G. Each is linked with RNASEH1 in more than 5 cancer types. Because this analysis shows association rather than direction, both RNASEH1-to-partner and partner-to-RNASEH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNASEH1 versus SNRNP200 in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH1→partner) and Y-score (partner→RNASEH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRNP200 →	+0.215	+0.302	<.001	.001	3	6
LSCC	MSH2 →	+0.447	+0.345	<.001	<.001	3	6
HNSC	PPM1G →	+0.309	+0.839	<.001	<.001	3	6
LSCC	UTP4 →	+0.295	+0.323	<.001	<.001	3	6
UCEC	PRPF8 →	+0.240	+0.417	<.001	.003	3	6
LSCC	MSH6 →	+0.527	+0.375	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,900 associations by consensus.

RNASEH1 vs SNRNP200 — GBM

Explore this scatter interactively →