RNASEH1

Across TCGA patient cohorts, RNASEH1 mutation is significantly associated with the RNA expression of many other genes, with 205 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASEH1-associated genes across cancer lineages are ZNHIT3, OR4N3P, and RN7SKP79. Each is linked with RNASEH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEH1-to-partner and partner-to-RNASEH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNHIT3 grouped by RNASEH1-low versus RNASEH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH1→partner) and Y-score (partner→RNASEH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNHIT3 →	+0.525	+3.606	.004	.001	3	1
BLCA	OR4N3P →	+0.148	+5.685	.001	.003	3	1
COAD	RN7SKP79 →	+0.752	+5.080	.004	.008	3	1
COAD	RN7SKP37 →	+0.450	+6.003	.001	.002	3	1
COAD	RNU6-1141P →	+1.000	+5.693	<.001	.003	3	1
COAD	RNU6-396P →	+0.929	+5.283	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 205 associations by consensus.

ZNHIT3 by RNASEH1 expression — UCEC

Explore this box plot interactively →