RNASEH1

Across TCGA patient cohorts, RNASEH1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASEH1-associated genes across cancer lineages are Myosin-IIa_pS1943, Myosin-IIa, and MEK1. Each is linked with RNASEH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEH1-to-partner and partner-to-RNASEH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by RNASEH1-low versus RNASEH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH1→partner) and Y-score (partner→RNASEH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.346	+3.000	.002	.036	3	1
UCEC	Myosin-IIa →	+0.306	+3.177	.002	.010	3	1
UCEC	MEK1 →	+0.558	+3.169	.005	.020	2	1
UCEC	MSH2 →	-0.469	-3.169	<.001	.020	1	1
UCEC	p62 Lck ligand →	+0.579	+3.169	.001	.020	1	1
UCEC	Annexin-1 →	+0.719	+3.169	.012	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Myosin-IIa_pS1943 by RNASEH1 expression — UCEC

Explore this box plot interactively →