RNASEH1

Across TCGA cell cohorts, RNASEH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,066 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNASEH1-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase I promoter, Nucleolar large rRNA transcription by RNA polymerase I, and Resolution of mitotic recombination intermediates. Each is linked with RNASEH1 in more than 15 cancer types. Because this analysis shows association rather than direction, both RNASEH1-to-partner and partner-to-RNASEH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase I promoter grouped by RNASEH1-low versus RNASEH1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH1→partner) and Y-score (partner→RNASEH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Transcription initiation at RNA polymerase I promoter →	+0.137	+1.020	<.001	<.001	3	16
OESOPHAGUS	Nucleolar large rRNA transcription by RNA polymerase I →	+0.111	+0.799	.005	.003	2	16
BONE	Resolution of mitotic recombination intermediates →	+0.151	+0.614	.001	.001	3	15
OESOPHAGUS	Transcription by RNA polymerase I →	+0.104	+0.755	.003	.004	3	14
PANCREAS	Mitotic sister chromatid segregation →	+0.084	+0.768	.002	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Metaphase/anaphase transition of mitotic cell cycle →	+0.138	+1.013	.002	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,066 associations by consensus.

Transcription initiation at RNA polymerase I promoter by RNASEH1 expression — PANCREAS

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