RNASEH1-AS1

Across TCGA pan-cancer cohorts, RNASEH1-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RNASEH1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RNASEH1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNASEH1-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, THCA, and KICH are the cancer types where RNASEH1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASEH1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.211	<.001	11	view →
THCA	Male	III,IV	−1.112	<.001	10	view →
KICH	Female	II,III,IV	−1.801	<.001	8	view →
LIHC	Male	II,III,IV	+1.195	<.001	8	view →
KIRC	All	II,III,IV	−0.385	<.001	5	view →
STAD	All	II,III,IV	+0.724	.004	4	view →
CHOL	All	All	+1.612	<.001	3	view →
READ	All	II,III,IV	+0.765	.019	3	view →
LUAD	All	All	+0.431	<.001	3	view →
HNSC	All	All	+0.326	.031	3	view →
ESCA	All	All	+1.012	.005	2	view →
LUSC	All	All	+0.378	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RNASEH1-AS1–COAD

Open the COAD breakdown →