RNASE6

Across TCGA patient cohorts, RNASE6 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,405 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RNASE6-associated proteins across cancer lineages are ARHGAP45, DOCK2, and AIF1. Each is linked with RNASE6 in more than 9 cancer types. Because this analysis shows association rather than direction, both RNASE6-to-partner and partner-to-RNASE6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNASE6 versus ARHGAP45 in GBM, with a Pearson correlation of 0.70.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE6→partner) and Y-score (partner→RNASE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.662	+0.843	<.001	<.001	3	10
GBM	DOCK2 →	+0.787	+1.159	<.001	<.001	3	10
GBM	AIF1 →	+0.967	+1.146	<.001	<.001	3	10
HNSC	EVL →	+0.691	+0.954	<.001	<.001	3	10
GBM	HCLS1 →	+0.904	+1.152	<.001	<.001	3	10
GBM	IL16 →	+0.683	+1.036	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,405 associations by consensus.

RNASE6 vs ARHGAP45 — GBM

Explore this scatter interactively →