RNASE6

Across TCGA pan-cancer cohorts, RNASE6 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RNASE6 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNASE6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RNASE6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where RNASE6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.695	0.475	<.001	78	view →
SKCM	OS	Median	All	0.402	0.270	<.001	75	view →
UVM	DFS	Median	All	0.393	0.821	<.001	73	view →
CESC	DFS	Tertile	All	0.821	0.644	.001	58	view →
LGG	OS	Median	All	0.358	0.544	<.001	53	view →
LUAD	DFS	Median	All	0.841	0.739	.002	45	view →
UCEC	DFS	Tertile	III,IV	0.768	0.378	.011	26	view →
GBM	DFS	Median	All	0.196	0.393	.005	20	view →
ACC	OS	Median	III,IV	0.604	0.859	.007	15	view →
CHOL	DFS	Quartile	All	0.799	0.128	.002	12	view →
STAD	OS	Tertile	III,IV	0.711	0.492	.014	12	view →
OV	OS	Quartile	IV	0.679	0.842	.022	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

RNASE6–HNSC (DFS)

Open the HNSC breakdown →