RNASE6

Across TCGA patient cohorts, RNASE6 protein abundance is significantly associated with the RNA expression of many other genes, with 11,467 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RNASE6-associated genes across cancer lineages are LILRB3, IL16, and CSF1R. Each is linked with RNASE6 in more than 7 cancer types. Because this analysis shows association rather than direction, both RNASE6-to-partner and partner-to-RNASE6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNASE6 versus LILRB3 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE6→partner) and Y-score (partner→RNASE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LILRB3 →	+1.027	+0.687	<.001	<.001	3	8
OV	IL16 →	+0.872	+0.648	<.001	<.001	3	8
OV	CSF1R →	+1.078	+0.523	.001	.004	3	8
BRCA	NCF4 →	+1.000	+0.537	<.001	<.001	3	7
HNSC	ATP8B4 →	+0.694	+0.587	<.001	<.001	3	7
BRCA	PLCB2 →	+0.868	+0.525	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,467 associations by consensus.

RNASE6 vs LILRB3 — GBM

Explore this scatter interactively →