RNASE6

Across TCGA patient cohorts, RNASE6 mutation is significantly associated with the RNA expression of many other genes, with 164 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE6-associated genes across cancer lineages are PACRG-AS2, PGAP2, and ANKRD9. Each is linked with RNASE6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE6-to-partner and partner-to-RNASE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PACRG-AS2 grouped by RNASE6-low versus RNASE6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE6→partner) and Y-score (partner→RNASE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PACRG-AS2 →	+0.038	+4.970	<.001	.005	3	2
UCEC	PGAP2 →	+0.489	+3.470	.006	.003	3	1
UCEC	ANKRD9 →	+0.632	+3.470	.001	.003	3	1
UCEC	MVD →	+0.753	+3.491	.001	.002	3	1
UCEC	CDT1 →	+0.949	+3.491	.001	.002	3	1
UCEC	CHAF1A →	+0.865	+3.480	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 164 associations by consensus.

PACRG-AS2 by RNASE6 expression — SKCM

Explore this box plot interactively →