RNASE6

Across TCGA patient cohorts, RNASE6 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE6-associated genes across cancer lineages are ATM, Rab25, and p27_pT198. Each is linked with RNASE6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE6-to-partner and partner-to-RNASE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RNASE6-low versus RNASE6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE6→partner) and Y-score (partner→RNASE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.606	-3.000	.020	.037	3	1
UCEC	Rab25 →	-0.514	-3.000	.007	.037	2	1
UCEC	p27_pT198 →	+0.129	+3.000	.037	.037	1	1
UCEC	c-Met_pY1235 →	+0.095	+3.000	.027	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ATM by RNASE6 expression — UCEC

Explore this box plot interactively →