RNASE6

Across TCGA cell cohorts, RNASE6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,836 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNASE6-associated GO terms across cancer lineages are Regulation of PERK-mediated unfolded protein response, Macropinocytosis, and Regulation of cytotoxic T cell degranulation. Each is linked with RNASE6 in more than 4 cancer types. Because this analysis shows association rather than direction, both RNASE6-to-partner and partner-to-RNASE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of PERK-mediated unfolded protein response grouped by RNASE6-low versus RNASE6-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE6→partner) and Y-score (partner→RNASE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of PERK-mediated unfolded protein response →	+0.059	+0.037	.001	.004	3	5
BLOOD_Leukemia	Macropinocytosis →	+0.117	+1.484	<.001	<.001	3	5
BLOOD_Myeloma	Regulation of cytotoxic T cell degranulation →	+1.077	+1.640	.001	.009	3	5
BLOOD_Myeloma	Negative regulation of cytotoxic T cell degranulation →	+1.077	+1.640	.001	.009	3	5
LARGE_INTESTINE	Positive regulation of hemostasis →	-0.111	-0.720	<.001	.002	3	5
LARGE_INTESTINE	Secondary alcohol metabolic process →	+0.053	+0.684	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,836 associations by consensus.

Regulation of PERK-mediated unfolded protein response by RNASE6 expression — CNS

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