RNASE2

Across TCGA patient cohorts, RNASE2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,821 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RNASE2-associated genes across cancer lineages are LILRB2, MEFV, and CEACAM4. Each is linked with RNASE2 in more than 6 cancer types. Because this analysis shows association rather than direction, both RNASE2-to-partner and partner-to-RNASE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNASE2 versus LILRB2 in GBM, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE2→partner) and Y-score (partner→RNASE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LILRB2 →	+1.017	+0.625	<.001	<.001	3	7
LSCC	MEFV →	+0.804	+0.437	<.001	<.001	3	6
LSCC	CEACAM4 →	+1.062	+0.494	<.001	<.001	3	6
HNSC	MMP25 →	+0.599	+0.507	.004	<.001	3	6
HNSC	CLC →	+2.125	+0.663	<.001	<.001	3	5
LUAD	BCL7A →	-0.538	-0.281	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,821 associations by consensus.

RNASE2 vs LILRB2 — GBM

Explore this scatter interactively →