RNASE2

Across TCGA cell cohorts, RNASE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,441 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNASE2-associated GO terms across cancer lineages are Neutrophil-mediated killing of fungus, Regulation of calcium ion export across plasma membrane, and Disruption of plasma membrane integrity in another organism. Each is linked with RNASE2 in more than 6 cancer types. Because this analysis shows association rather than direction, both RNASE2-to-partner and partner-to-RNASE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophil-mediated killing of fungus grouped by RNASE2-low versus RNASE2-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE2→partner) and Y-score (partner→RNASE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Neutrophil-mediated killing of fungus →	+1.160	+4.291	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of calcium ion export across plasma membrane →	+0.076	+0.059	.001	.002	3	6
BLOOD_Leukemia	Disruption of plasma membrane integrity in another organism →	+0.868	+3.829	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.066	+0.050	.004	.001	3	5
BLOOD_Leukemia	Multivesicular body organization →	+0.061	+2.884	<.001	<.001	3	5
BLOOD_Myeloma	Endosome organization →	+0.067	+0.226	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,441 associations by consensus.

Neutrophil-mediated killing of fungus by RNASE2 expression — BLOOD_Leukemia

Explore this box plot interactively →