RNASE12

Across TCGA cell cohorts, RNASE12 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RNASE12-associated genes across cancer lineages are OR10W1, TNP1, and CABS1. Each is linked with RNASE12 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE12-to-partner and partner-to-RNASE12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by RNASE12-low versus RNASE12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE12→partner) and Y-score (partner→RNASE12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	TNP1 →	+0.160	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	CABS1 →	+0.019	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	DAOA →	+0.023	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR1P1 →	+0.048	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR10W1 by RNASE12 expression — LARGE_INTESTINE

Explore this box plot interactively →