RNASE11

Across TCGA patient cohorts, RNASE11 mutation is significantly associated with the RNA expression of many other genes, with 1,455 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE11-associated genes across cancer lineages are VAC14, MRPL37, and RNU6-142P. Each is linked with RNASE11 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE11-to-partner and partner-to-RNASE11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAC14 grouped by RNASE11-low versus RNASE11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE11→partner) and Y-score (partner→RNASE11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VAC14 →	+0.527	+3.625	<.001	.001	3	2
UCEC	MRPL37 →	+0.607	+3.807	<.001	<.001	3	2
SKCM	RNU6-142P →	+0.182	+3.186	.003	.009	3	2
UCEC	PIP4K2C →	+0.583	+2.700	.002	.006	3	2
LUAD	SLC35G4 →	+0.023	+4.399	.003	.008	3	2
STAD	RNU6-1207P →	+0.945	+5.147	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,455 associations by consensus.

VAC14 by RNASE11 expression — UCEC

Explore this box plot interactively →