RNASE11

Across TCGA pan-cancer cohorts, RNASE11 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated RNASE11 data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RNASE11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RNASE11 expression acts as an unfavorable survival marker, although some lineages such as ACC and THCA show a favorable association.

ACC, SCLC, and SKCM are the cancer types where RNASE11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.808	0.474	<.001	96	view →
SCLC	OS	Tertile	All	0.096	0.716	<.001	54	view →
SKCM	DFS	Tertile	All	0.171	0.739	<.001	54	view →
LUSC	OS	Tertile	All	0.157	0.660	.003	36	view →
BRCA	DFS	Tertile	All	0.546	0.903	<.001	36	view →
COAD	OS	Tertile	II,III,IV	0.202	0.788	.013	18	view →
UCS	DFS	Tertile	All	0.126	0.523	.009	18	view →
TGCT	DFS	Tertile	II,III,IV	0.621	0.949	.034	18	view →
THYM	OS	Tertile	II,III,IV	0.395	0.863	.014	12	view →
STAD	DFS	Tertile	III,IV	0.178	0.496	.024	9	view →
THCA	OS	Tertile	III,IV	1.000	0.919	.030	5	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

RNASE11–ACC (OS)

Open the ACC breakdown →