RNASE11

Across TCGA patient cohorts, RNASE11 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE11-associated genes across cancer lineages are ASNS, JNK_pT183_Y185, and PCNA. Each is linked with RNASE11 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE11-to-partner and partner-to-RNASE11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RNASE11-low versus RNASE11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE11→partner) and Y-score (partner→RNASE11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.530	+3.000	.002	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.164	-3.000	.044	.036	3	1
UCEC	PCNA →	+0.247	+2.459	.017	.020	3	1
UCEC	Axl →	+0.212	+2.358	.041	.019	3	1
UCEC	VHL →	-1.263	-2.321	<.001	.034	3	1
UCEC	c-Jun_pS73 →	-0.161	-3.160	.036	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ASNS by RNASE11 expression — UCEC

Explore this box plot interactively →