RNASE11

Across TCGA cell cohorts, RNASE11 RNA expression is significantly associated with the mutation status of many other genes, with 56 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNASE11-associated genes across cancer lineages are AMER1, RSPO3, and ZNF618. Each is linked with RNASE11 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE11-to-partner and partner-to-RNASE11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMER1 grouped by RNASE11-low versus RNASE11-high in LUNG_NSCLC_LUAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE11→partner) and Y-score (partner→RNASE11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AMER1 →	+4.228	+0.112	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	RSPO3 →	+5.357	+0.099	.003	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ZNF618 →	+4.357	+0.075	.006	<.001	3	2
BLOOD_Myeloma	MEI1 →	+4.700	+0.050	<.001	<.001	3	1
BLOOD_Myeloma	MYH13 →	+4.285	+0.039	.003	<.001	3	1
BONE	GLI3 →	+5.169	+0.036	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

AMER1 by RNASE11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →