Across TCGA pan-cancer cohorts, RNA5SP450 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNA5SP450’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNA5SP450 RNA is repressed in tumor relative to normal tissue. In most cancer types RNA5SP450 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where RNA5SP450 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNA5SP450 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.620	.006	4	view →
KIRC	All	All	−0.169	.003	4	view →
LUAD	Female	II,III,IV	−0.723	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNA5SP450 RNA expression & survival · all RNA5SP450 data types