RMST

Across TCGA pan-cancer cohorts, RMST RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated RMST data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher RMST RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RMST expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, KIRC, and LGG are the cancer types where RMST RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	III,IV	0.954	0.827	.002	52	view →
KIRC	DFS	Tertile	All	0.858	0.726	<.001	47	view →
LGG	DFS	Median	All	0.665	0.804	<.001	43	view →
BLCA	DFS	Tertile	III,IV	0.223	0.480	.006	26	view →
DLBC	OS	Tertile	II,III,IV	0.294	1.000	.013	21	view →
READ	DFS	Quartile	All	0.540	0.742	.007	21	view →
SKCM	OS	Tertile	IV	0.247	0.752	.004	18	view →
ACC	DFS	Quartile	III,IV	0.114	0.698	.001	18	view →
PAAD	DFS	Median	II,III,IV	0.573	0.352	.007	17	view →
PRAD	DFS	Median	All	0.912	0.952	.002	14	view →
THYM	DFS	Tertile	All	1.000	0.680	.023	12	view →
MESO	OS	Quartile	II,III,IV	0.129	0.539	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

RMST–BRCA (DFS)

Open the BRCA breakdown →