RMST

Across TCGA pan-cancer cohorts, RMST RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RMST’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RMST RNA is repressed in tumor relative to normal tissue. In most cancer types RMST is over-expressed in tumor, although a few such as KIRP and LUAD show the opposite, repressed pattern.

KIRP, LUAD, and LUSC are the cancer types where RMST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RMST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−0.512	<.001	10	view →
LUAD	Female	III,IV	−0.977	<.001	9	view →
LUSC	All	All	−0.571	<.001	9	view →
BRCA	Female	All	−0.289	<.001	6	view →
LIHC	All	All	+0.168	<.001	6	view →
HNSC	All	All	−0.088	.004	6	view →
UCEC	All	All	−1.016	.006	4	view →
CHOL	All	All	+0.265	.013	2	view →
KIRC	All	All	−0.148	.011	2	view →
STAD	All	III,IV	−0.077	.022	2	view →
COAD	Female	All	−0.029	.006	2	view →
READ	All	All	−0.021	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RMST–KIRP

Open the KIRP breakdown →