RMND5B

Across TCGA patient cohorts, RMND5B mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RMND5B-associated genes across cancer lineages are eIF4E, ER-alpha, and G6PD. Each is linked with RMND5B in more than 1 cancer types. Because this analysis shows association rather than direction, both RMND5B-to-partner and partner-to-RMND5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RMND5B-low versus RMND5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RMND5B→partner) and Y-score (partner→RMND5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.231	+2.584	.004	.001	3	1
UCEC	ER-alpha →	+0.700	+1.700	.026	.042	3	1
UCEC	G6PD →	-0.268	-2.308	.030	.033	3	1
UCEC	JNK2 →	+0.243	+3.196	.001	.009	3	1
UCEC	MEK1 →	+0.368	+2.584	.008	.001	3	1
UCEC	MSH2 →	-0.212	-3.143	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by RMND5B expression — UCEC

Explore this box plot interactively →