RMND5B

Across TCGA pan-cancer cohorts, RMND5B RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RMND5B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RMND5B RNA is repressed in tumor relative to normal tissue. In most cancer types RMND5B is over-expressed in tumor, although a few such as HNSC and LUSC show the opposite, repressed pattern.

HNSC, LIHC, and BRCA are the cancer types where RMND5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RMND5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−1.044	<.001	12	view →
LIHC	Female	II,III,IV	+1.190	<.001	9	view →
BRCA	All	III,IV	+0.833	<.001	6	view →
COAD	Female	All	+0.419	<.001	6	view →
KIRP	All	II,III,IV	+0.350	.012	6	view →
LUSC	All	All	−0.281	.001	4	view →
CHOL	Female	All	+1.796	<.001	3	view →
STAD	Female	III,IV	−0.550	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RMND5B–HNSC

Open the HNSC breakdown →