RMND5A

Across TCGA patient cohorts, RMND5A mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RMND5A-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1173, and FASN. Each is linked with RMND5A in more than 1 cancer types. Because this analysis shows association rather than direction, both RMND5A-to-partner and partner-to-RMND5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by RMND5A-low versus RMND5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RMND5A→partner) and Y-score (partner→RMND5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.158	-2.980	.022	.036	3	2
UCEC	EGFR_pY1173 →	+0.083	+1.901	.025	.031	3	1
UCEC	FASN →	+0.542	+3.169	.003	.019	3	1
UCEC	FoxM1 →	+0.289	+3.179	.016	.010	3	1
UCEC	ACC1 →	+0.503	+3.013	.002	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.222	-2.571	.004	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

mTOR_pS2448 by RMND5A expression — UCEC

Explore this box plot interactively →