RLN1

Across TCGA cell cohorts, RLN1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RLN1-associated genes across cancer lineages are SLC17A2, GPR31, and CST8. Each is linked with RLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RLN1-to-partner and partner-to-RLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A2 grouped by RLN1-low versus RLN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLN1→partner) and Y-score (partner→RLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC17A2 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GPR31 →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CST8 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	EDDM3A →	+0.380	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR6S1 →	+0.049	+4.977	<.001	.007	3	1
LARGE_INTESTINE	FIGLA →	+0.051	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SLC17A2 by RLN1 expression — LARGE_INTESTINE

Explore this box plot interactively →