RLF

Across TCGA patient cohorts, RLF mutation is significantly associated with the RNA expression of many other genes, with 2,855 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RLF-associated genes across cancer lineages are MRPS15, BNIP3, and UFD1. Each is linked with RLF in more than 2 cancer types. Because this analysis shows association rather than direction, both RLF-to-partner and partner-to-RLF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS15 grouped by RLF-low versus RLF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RLF→partner) and Y-score (partner→RLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS15 →	+0.340	+1.523	<.001	<.001	3	3
UCEC	BNIP3 →	+0.503	+1.192	.004	.008	3	3
SKCM	UFD1 →	+0.327	+3.360	.007	.004	3	3
UCEC	SVIP →	+0.440	+1.652	<.001	.005	3	3
READ	RNA5SP452 →	+0.689	+4.724	<.001	.003	3	2
READ	RNU6-110P →	+0.741	+4.445	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,855 associations by consensus.

MRPS15 by RLF expression — UCEC

Explore this box plot interactively →