RIT1

Across TCGA patient cohorts, RIT1 mutation is significantly associated with the RNA expression of many other genes, with 361 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIT1-associated genes across cancer lineages are RNU6-435P, SNX18P14, and LINC02862. Each is linked with RIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIT1-to-partner and partner-to-RIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-435P grouped by RIT1-low versus RIT1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIT1→partner) and Y-score (partner→RIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-435P →	+0.205	+4.297	.001	.009	3	2
CESC	SNX18P14 →	+0.320	+4.234	<.001	.008	3	1
CESC	LINC02862 →	+0.209	+4.364	<.001	.006	3	1
CESC	RPL9P15 →	+0.049	+4.969	<.001	.004	3	1
CESC	RN7SL647P →	+0.153	+6.584	<.001	<.001	3	1
CESC	RIC3-DT →	+0.025	+4.234	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 361 associations by consensus.

RNU6-435P by RIT1 expression — LUSC

Explore this box plot interactively →