RIT1

Across TCGA pan-cancer cohorts, RIT1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RIT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RIT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RIT1 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where RIT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RIT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.437	<.001	12	view →
KICH	Female	II,III,IV	−1.827	<.001	10	view →
LIHC	Female	II,III,IV	+1.382	<.001	9	view →
HNSC	All	II,III,IV	+0.667	<.001	9	view →
KIRP	All	All	+0.573	<.001	9	view →
BLCA	All	All	+0.604	.002	6	view →
BRCA	All	III,IV	+0.525	<.001	6	view →
CHOL	All	II,III,IV	+3.465	<.001	5	view →
LUAD	All	All	+0.388	<.001	3	view →
LUSC	All	All	+0.489	<.001	2	view →
UCEC	All	All	+0.417	.038	2	view →
PRAD	All	All	−0.266	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RIT1–KIRC

Open the KIRC breakdown →