RIT1

Across TCGA cell cohorts, RIT1 mutation is significantly associated with the mutation status of many other genes, with 2,529 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIT1-associated genes across cancer lineages are MTMR3, APOL4, and GRAP2. Each is linked with RIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIT1-to-partner and partner-to-RIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTMR3 grouped by RIT1-low versus RIT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIT1→partner) and Y-score (partner→RIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MTMR3 →	+5.894	+5.321	.002	.002	1	2
BLOOD_Leukemia	APOL4 →	+5.894	+5.321	.002	.002	1	2
BLOOD_Leukemia	GRAP2 →	+4.894	+4.894	.004	.004	1	2
BLOOD_Leukemia	POLE2 →	+5.894	+5.321	.002	.002	1	2
BLOOD_Leukemia	NFATC4 →	+3.672	+5.083	.001	.001	1	2
BLOOD_Leukemia	PYGB →	+2.894	+4.432	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,529 associations by consensus.

MTMR3 by RIT1 expression — BLOOD_Leukemia

Explore this box plot interactively →