RIPPLY1

Across TCGA patient cohorts, RIPPLY1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIPPLY1-associated genes across cancer lineages are PDCD4, PKC-a_pS657, and VHL. Each is linked with RIPPLY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPPLY1-to-partner and partner-to-RIPPLY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by RIPPLY1-low versus RIPPLY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPPLY1→partner) and Y-score (partner→RIPPLY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.591	-2.990	.007	.036	3	1
UCEC	PKC-a_pS657 →	+0.416	+1.887	.019	.031	3	1
UCEC	VHL →	-0.743	-2.321	.018	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+1.327	+2.479	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.351	+2.817	.020	.036	2	1
UCEC	PKC-a →	+0.505	+3.169	.007	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PDCD4 by RIPPLY1 expression — UCEC

Explore this box plot interactively →