RIPPLY1

Across TCGA pan-cancer cohorts, RIPPLY1 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated RIPPLY1 data layer compared with 4 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher RIPPLY1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RIPPLY1 expression acts as an unfavorable survival marker, although some lineages such as THCA and UCS show a favorable association.

THCA, UCS, and LAML are the cancer types where RIPPLY1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	All	0.931	0.781	.002	48	view →
UCS	DFS	Tertile	II,III,IV	0.578	0.258	.020	46	view →
LAML	DFS	Tertile	All	0.220	0.431	.012	36	view →
DLBC	DFS	Tertile	All	0.474	0.930	.002	32	view →
HNSC	OS	Median	All	0.621	0.747	.003	28	view →
LIHC	OS	Quartile	III,IV	0.783	0.246	<.001	27	view →
KIRP	DFS	Tertile	II,III,IV	0.829	0.288	.013	24	view →
BRCA	DFS	Median	IV	0.345	0.788	.004	19	view →
TGCT	DFS	Quartile	All	0.454	0.749	.001	18	view →
UVM	DFS	Tertile	All	0.274	0.798	.002	18	view →
CHOL	OS	Median	II,III,IV	0.321	0.744	.017	15	view →
STAD	DFS	Quartile	III,IV	0.386	0.589	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

RIPPLY1–THCA (DFS)

Open the THCA breakdown →