RIPOR2

Across TCGA patient cohorts, RIPOR2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIPOR2-associated genes across cancer lineages are Shc_pY317, ATM, and 4E-BP1. Each is linked with RIPOR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIPOR2-to-partner and partner-to-RIPOR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by RIPOR2-low versus RIPOR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPOR2→partner) and Y-score (partner→RIPOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.148	-1.321	<.001	.005	3	2
UCEC	ATM →	-0.468	-1.678	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.209	+1.000	.005	.033	3	2
COAD	C-Raf →	+0.256	+3.178	<.001	.010	3	2
UCEC	eEF2K →	+0.207	+1.584	.032	.017	3	2
COAD	PDCD4 →	-0.521	-3.161	.012	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Shc_pY317 by RIPOR2 expression — UCEC

Explore this box plot interactively →