RIPOR2

Across TCGA pan-cancer cohorts, RIPOR2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RIPOR2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RIPOR2 RNA is repressed in tumor relative to normal tissue. In most cancer types RIPOR2 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where RIPOR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RIPOR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.625	<.001	11	view →
KIRC	Female	All	+1.131	<.001	11	view →
LUAD	Male	III,IV	−1.263	<.001	8	view →
COAD	Female	All	−0.877	<.001	8	view →
BLCA	All	All	−0.871	<.001	8	view →
UCEC	All	All	−2.779	<.001	6	view →
LUSC	Female	All	−1.722	<.001	6	view →
BRCA	All	III,IV	−0.823	<.001	6	view →
THCA	All	III,IV	+0.822	.013	5	view →
PRAD	All	All	−0.822	<.001	2	view →
LIHC	Male	All	−0.278	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RIPOR2–KICH

Open the KICH breakdown →