RIPOR2

Across TCGA cell cohorts, RIPOR2 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIPOR2-associated genes across cancer lineages are SHCBP1L, USP17L3, and DYTN. Each is linked with RIPOR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIPOR2-to-partner and partner-to-RIPOR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1L grouped by RIPOR2-low versus RIPOR2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPOR2→partner) and Y-score (partner→RIPOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SHCBP1L →	+0.241	+3.232	.004	.008	3	2
LUNG_NSCLC_LUSC	USP17L3 →	+0.024	+4.584	.001	.001	3	1
LUNG_NSCLC_LUSC	DYTN →	+0.007	+4.108	<.001	.005	3	1
LUNG_SCLC	OR52H1 →	+0.042	+3.256	.006	.005	3	1
LUNG_SCLC	SCYGR10 →	+0.188	+3.232	.001	.008	3	1
LARGE_INTESTINE	CHMP4B →	-0.641	-3.278	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

SHCBP1L by RIPOR2 expression — LUNG_SCLC

Explore this box plot interactively →