RIPK3

Across TCGA patient cohorts, RIPK3 mutation is significantly associated with the RNA expression of many other genes, with 3,067 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIPK3-associated genes across cancer lineages are MIR378F, SEPTIN14P24, and OR8F1P. Each is linked with RIPK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIPK3-to-partner and partner-to-RIPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR378F grouped by RIPK3-low versus RIPK3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIPK3→partner) and Y-score (partner→RIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR378F →	+0.486	+7.342	<.001	<.001	3	3
LUAD	SEPTIN14P24 →	+0.369	+5.928	<.001	<.001	3	2
LUAD	OR8F1P →	+0.058	+4.554	.002	.009	3	2
LUAD	SSX2 →	+0.120	+4.481	<.001	.009	3	2
SKCM	MRPL36 →	+0.365	+3.604	.009	.001	3	2
SKCM	DALRD3 →	+0.460	+2.913	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,067 associations by consensus.

MIR378F by RIPK3 expression — LUAD

Explore this box plot interactively →