RIOX2

Across TCGA cell cohorts, RIOX2 mutation is significantly associated with the RNA expression of many other genes, with 446 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIOX2-associated genes across cancer lineages are F11, MFSD6L, and GZMH. Each is linked with RIOX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIOX2-to-partner and partner-to-RIOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F11 grouped by RIOX2-low versus RIOX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOX2→partner) and Y-score (partner→RIOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	F11 →	+0.032	+2.882	.001	.001	3	3
LARGE_INTESTINE	MFSD6L →	+0.806	+3.212	<.001	.006	3	2
STOMACH	GZMH →	+0.037	+4.285	<.001	.007	3	1
BLOOD_Lymphoma	ARMS2 →	+0.024	+4.867	.002	.009	3	1
UPPER_AERODIGESTIVE_TRACT	ACTRT1 →	+0.052	+3.870	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CSH1 →	+0.059	+3.917	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 446 associations by consensus.

F11 by RIOX2 expression — LARGE_INTESTINE

Explore this box plot interactively →