RINT1

Across TCGA cell cohorts, RINT1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RINT1-associated genes across cancer lineages are TRHR, OR3A1, and FTMT. Each is linked with RINT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RINT1-to-partner and partner-to-RINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRHR grouped by RINT1-low versus RINT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RINT1→partner) and Y-score (partner→RINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRHR →	+0.049	+2.906	<.001	.008	3	2
STOMACH	OR3A1 →	+0.093	+5.285	<.001	.003	3	1
STOMACH	FTMT →	+0.066	+5.285	<.001	.003	3	1
STOMACH	FOXB2 →	+0.013	+5.285	<.001	.003	3	1
LUNG_SCLC	OR5T2 →	+0.020	+5.643	<.001	.002	3	1
LUNG_SCLC	OR5H6 →	+0.025	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

TRHR by RINT1 expression — LARGE_INTESTINE

Explore this box plot interactively →