Across TCGA cell cohorts, RING1 mutation is significantly associated with the RNA expression of many other genes, with 476 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RING1-associated genes across cancer lineages are FOXR1, OR14A16, and TEX51. Each is linked with RING1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RING1-to-partner and partner-to-RING1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RING1→partner) and Y-score (partner→RING1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FOXR1 →	+0.281	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	OR14A16 →	+0.009	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	TEX51 →	+0.015	+4.058	<.001	.009	3	1
LARGE_INTESTINE	TNRC6B →	+0.911	+3.364	<.001	.002	3	1
LARGE_INTESTINE	FZD3 →	+0.791	+3.364	.001	.002	3	1
LARGE_INTESTINE	HFE →	+0.893	+3.364	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 476 associations by consensus.

Exploration

RING1 survival (RNA) · tumor vs normal (RNA) · all RING1 data types