RIN3

Across TCGA cell cohorts, RIN3 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RIN3-associated genes across cancer lineages are ZNF804B, SSMEM1, and CSH1. Each is linked with RIN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIN3-to-partner and partner-to-RIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF804B grouped by RIN3-low versus RIN3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIN3→partner) and Y-score (partner→RIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF804B →	+0.006	+5.087	<.001	.004	3	3
LARGE_INTESTINE	SSMEM1 →	+0.020	+3.252	.002	<.001	3	2
BLOOD_Leukemia	CSH1 →	+0.040	+4.339	<.001	.002	3	2
BLOOD_Leukemia	KHDC3L →	+0.321	+3.774	<.001	.008	3	2
URINARY_TRACT	IL17F →	+0.056	+5.087	<.001	.004	3	1
URINARY_TRACT	OR52N4 →	+0.023	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ZNF804B by RIN3 expression — URINARY_TRACT

Explore this box plot interactively →